From Premature Gray Hair To Helicase - Werner Syndrome

From Premature Gray Hair To Helicase - Werner Syndrome by M Goto Download PDF EPUB FB2

Genre/Form: Aufsatzsammlung: Additional Physical Format: Online version: Goto, Makoto. From premature gray hair to helicase-- Werner syndrome. Tokyo:   From Premature Gray Hair to Helicase-Werner Syndrome: Implications for Aging and Cancer (Gann Monograph on Cancer Research, No.

49) [M. Goto, R.W. Miller, Monograph Committee Japanese Cancer Association] on *FREE* shipping on qualifying offers. Werner Syndrome --   Read and Dowload Now ?book= トップ＞From premature gray hair to helicase - Werner syndrome implications for aging and cancer From premature gray hair to helicase - Werner syndrome implications for aging and cancer [書誌情報] 責任表示: edited by Makoto Goto, Robert W.

Miller 出版者: From premature gray hair to helicase - werner syndrome: implications for aging and cancer edited by Makoto Goto, and Robert W.

Miller （Gann monograph on cancer research / Japanese Cancer Association, no. 49） Japan Scientific Societies Press, Karger, ja sz   From premature gray hair to helicase - werner syndrome: implications for aging and cancer / edited by Makoto Goto, and Robert W.

Miller 資料形態: 図書 形態: x, p. ; 27 cm 出版情報: Werner syndrome is an inherited disease characterized by premature aging, genetic instability and a high incidence of cancer. The wild type Werner syndrome protein (WRN) has been demonstrated to   Introduction.

Werner syndrome (WS, OMIM #) is an autosomal recessive disease caused by loss of function mutations in the WRN gene. WS patients develop features reminiscent of premature aging beginning in the second decade of life, including bilateral cataracts, graying and loss of hair, scleroderma-like skin changes, diabetes mellitus, and osteoporosis (Table 1).

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Miller. Country of Publication: Japan Publisher: Tokyo: New York: Japan Scientific Societies Press ; Karger, c   Werner syndrome (WS) (Mendelian Inheritance in Man no. ) is an autosomal recessive disorder known for progeroid phenotypes including graying and loss of hair, juvenile cataracts, insulin-resistant diabetes, skin atrophy, premature atherosclerosis, and cancer From Premature Gray Hair To Helicase - Werner Syndrome book.

Mutations in WRN, a RECQ family DNA/RNA helicase gene, have been identified to cause this :// Werner Syndrome Helicase. Werner syndrome helicase (WRN) was the second member of the RECQ family of DNA helicases to be discovered in humans. The WRN gene was cloned in in an attempt to identify the genetic alterations that cause Werner syndrome (WS) [97], a disease first described by Otto Werner, a German medical student, in [].

Werner syndrome is caused by a homozygous or compound heterozygous mutation in the RECQL2 geneWS, which provides instructions to a protein called helicase. This is a homolog of the E. coli RecQ DNA helicase and is found on chromosome 8p Helicase affects the way DNA and RNA are replicated and repaired in the :// Werner Syndrome.

Werner syndrome is an autosomal recessive disease also associated with premature aging []. Werner syndrome has a significant ethnic association []. The incidence is much higher in Japan, 1 inin the general population []. In contrast, Werner syndrome is only found in 1 in 1, outside of Japan From Premature Gray Hair to Helicase-Werner Syndrome: Implications for Aging and Cancer Chapter: "A Brief History of Research on the Werner Syndrome." Page 1 - 10 Martin GM Editors: M.

Goto and R. Scientific Societies Press, Tokyo, Japan   Monnat RJ Jr. Cancer patho-genesis in the human RecQ helicase deficiency syndromes. In: Goto M., Miller RW eds. From premature gray hair to helicase: Werner syndrome implications for aging and cancer. Gann Monograph on Cancer Research ; –   Unwinding the molecular basis of the Werner syndrome Jiang-Cheng Shen, Lawrence A.

Loeb * Department of Pathology, Uni ersity of Washington, Seattle, WAUSA Received 24 January ; accepted 26 January Abstract Werner syndrome (WS) is an autosomal recessive disease manifested by the 1.

Introduction. Patients with Werner syndrome (WS) show a wide range of premature aging phenotypes accompanied by rare tumors ().The major premature aging phenotypes include gray hair, hoarseness, cataract, diabetes and malignancy ().However, phenotypes of WS are not necessarily identical to those of natural aging; for instance WS is not usually accompanied by hearing loss, presbyopia or Werner syndrome (WRN) is a rare autosomal recessive segmental progeroid syndrome.

Patients exhibit not only an appearance of accelerated aging (premature graying, thinning of hair, skin atrophy and atrophy of subcutaneous fat), but also several disorders commonly associated with aging, including bilateral cataracts, diabetes mellitus, osteoporosis, premature arteriosclerosis, and a variety of From premature gray hair to.

helicase-Werner syndrome: Implications for aging and. cancer. In: Monograph on Cancer Research. No, Japan Scientific Societies Press & Karger, T okyo, Japan, Goto M.

Clinical characteristics of Werner syndrome and other premature aging syndromes: pattern of aging in progeroid syndromes. In: Goto M, Miller RW, editors.

From Premature Gray Hair to Helicase – Werner Syndrome: Implications for Aging and Cancer. Tokyo, Japan: Japan Scientific Societies Press; pp. 27– Abstract: Werner syndrome (WS) is an autosomal recessive condition characterized by an early onset of age-related symptoms that include ocular cataracts, premature graying and loss of hair, arteriosclerosis and atherosclerosis, diabetes mellitus, osteoporosis, and a high incidence of some types of cancers.

A major motivation for the study of WS ;/13/re2. Monnat RJ Jr. () Cancer pathogenesis in the human RecQ helicase deficiency syndromes, in 'From Premature Gray Hair to Helicase: Werner Syndrome Implications for Aging and Cancer', edited by M.

Goto and R.W. Miller. GANN Monograph on Cancer Research Abstract. Werner syndrome is a hereditary premature aging disorder characterized by genome instability. The product of the gene defective in WS, WRN, is a helicase/exonuclease that presumably functions in DNA understand the DNA structures WRN acts upon in vivo, we examined its substrate preferences for unwound a 3′-single-stranded (ss)DNA-tailed duplex substrate INTRODUCTION.

Werner syndrome (WS) is an autosomal recessive disorder characterized by premature onset and an accelerated rate of development of major geriatric diseases, including atherosclerosis, diabetes mellitus, osteoporosis, cataract and menopause, and predisposition to sarcoma and carcinoma [].Atrophy of the skin and premature graying of the hair are also common in WS 1.

Introduction. The Werner syndrome (WS) is an autosomal recessive disorder causing symptoms of premature aging ().The causative gene of WS is the WRN gene encoding for WRN protein, a DNA helicase ().Another characteristic feature of this disorder is a much higher incidence of rare cancers ().Non-epithelial tumors, including soft-tissue sarcoma and benign meningioma, are associated with Prevalence of Werner syndrome gene mutations in the Japanese population: a genetic epidemiological study SATOH M From premature gray hair to helicase-Werner syndrome: implications for aging and cancer,被引用文献1件 The disease progeria type 2, also called Werner syndrome, belongs to the genetic defects.

The word progeria comes from Latin and means "premature aging". The Werner syndrome was first discovered by the Kiel doctor C.W. Otto Werner described in   Introduction. Werner syndrome (WS, OMIM #) is an autosomal recessive disease caused by loss of function mutations in the WRN gene.

WS patients develop features reminiscent of premature aging beginning in the second decade of life, including bilateral cataracts, graying and loss of hair, scleroderma-like skin changes, diabetes mellitus, and ://?id=/.

From Premature Gray Hair to Helicase–Werner Syndrome Implications for Aging and Cancer. Japan Scientific Societies Press, Tokyo View in Article(05)From premature gray hair to helicase — Werner syndrome: implications for aging and cancer Karger Basel 35 Google Scholar 9.

Matsumoto, T, Imamura, O, Goto, M, Furuichi, Y Characterization of the nuclear localization signal in the DNA helicase involved in Werner's syndrome Int J Mol Med 1 71 6 PubMed Google Scholar  Premature Gray Hair to Helicase: Werner Syndrome Implications for Aging and Cancer’, edited by M.

Goto and R.W. Miller. GANN Monograph on Cancer Research Prince, P.R., Emond, M.J. and Monnat, R.J., Jr. () Loss of Werner syndrome protein function promotes aberrant mitotic recombination Genes & Development